Cronkhite-canada syndrome: report of three cases and review of literature

2022-05-23 0 By

Cronkhite-canada syndrome: A report of three cases and literature Review abstract:Cronkhite-canada syndrome (CCS) is a non-genetic disease with rare clinical manifestations. It is mainly manifested as multiple gastrointestinal polyps under endoscopy, and the main clinical manifestations are gastrointestinal symptoms, skin pigmentation, alopecia, and shedding of thyroid.This paper analyzed the clinical characteristics and diagnosis and treatment process of 3 patients diagnosed with CCS in Qilu Hospital of Shandong University from August 2012 to September 2021, and reviewed the literature.Multiple gastrointestinal polyps were found under endoscopy in all 3 patients, with gastrointestinal symptoms as the main clinical manifestations, accompanied by alopecia, demethylation, skin pigmentation and other gastrointestinal manifestations. Glucocorticoids and Proton Pump Inhibitors (PPI) were the main treatment drugs.Diagnosis of CCS is based on history, physical examination, endoscopic findings of gastrointestinal polyps, and histopathology, with digestive endoscopy being the most direct method.Early diagnosis, corticosteroid-centered drug therapy, regular endoscopic monitoring and new treatment regimens may provide more practical experience for better prognosis in the future, in order to improve clinicians’ awareness and understanding of the disease and reduce missed diagnosis and misdiagnosis in clinical work.Source: Li Shuying, Lin Yingmin, Wang Min.Cronkhite-canada syndrome: A report of three cases and literature Review [J].Chinese General Practice, 2022. DOI: 10.12114/j.issn.1007-9572.2022.0244.